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ea0081rc3.7 | Rapid Communications 3: Thyroid 1 | ECE2022

Immune-related thyroid dysfunctions during PD-1/PD-L1 inhibitors and their association to the oncological outcome: new evidence

Ferrari Matteo , Anna Nervo Alice , Basile Sara , Migliore Enrica , D'Angelo Valentina , Gruosso Giovanni , Rosso Daniela , Retta Francesca , Piovesan Alessandro , Arvat Emanuela

Background: Immune checkpoint inhibitors (ICIs) showed impressive results in several malignancies; however, a large spectrum of immune-related adverse events (IRAEs) may occur, including thyroid dysfunction (DYSTHYR). IRAEs seem to be associated with better cancer outcome; limited data suggested that thyroid toxicity could be a predictor of response to ICIs.Patients and methods: We retrospectively evaluated all patients who started treatment with the pro...

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ea0073oc10.6 | Oral Communications 10: Thyroid | ECE2021

Impact of allogeneic stem cell transplantation on thyroid function

Felicetti Francesco , Zavattaro Marco , Faraci Danilo , Gatti Filippo , Dellacasa Chiara , Busca Alessandro , Arvat Emanuela , Rosso Daniela , Marinelli Lorenzo , Margherita Dionisi-Vici , Giaccone Luisa , Bruno Benedetto , Brignardello Enrico

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...

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Endocrine Abstracts

Immune-related thyroid dysfunctions during PD-1/PD-L1 inhibitors and their association to the oncological outcome: new evidence

Impact of allogeneic stem cell transplantation on thyroid function

BiosciAbstracts